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GSK's Zofran drug could help drug addicts
18 Feb 2009
Clinical Research
Scientists in the US are looking into additional applications for GlaxoSmithKline's (GSK's) drug for nausea and vomiting.
Researchers at Stanford University School of Medicine have found ondansetron, marketed under the name Zofran, can be used to help symptoms of withdrawal from addictive opiates.
The scientists have found that as it is a non-addictive drug it can help and has minimal chance of side effects when treating those addicted to strong painkillers, including heroin and morphine.
Larry Chu, assistant professor of anesthesia at the School of Medicine and lead author of the study, says "Opioid abuse is rising at a faster rate than any other type of illicit drug use, yet only about a quarter of those dependent on opioids seek treatment."
He says GSK's drug can help to treat the flu-like symptoms of withdrawal, such as insomnia, diarrhoea, nausea, vomiting and agitation.
The drug has been tested on mice who exhibit similar addictions to morphine as humans.
It was found to calm them and tests on humans have shown a significant reduction in withdrawal symptoms, compared to those without the drug.
Zofran, which comes in tablet and injectable forms, is used on pregnant women experiencing morning sickness and cancer patients undergoing chemotherapy.
